Buy IDRA-21 Powder for Advanced Laboratory Research in Europe

IDRA-21 (7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) represents a well-characterised, synthetic ampakine compound of significant interest to European neuropharmacology, analytical chemistry, and biochemical research laboratories. As a rigorously characterised analytical reference standard, this compound enables precise AMPA receptor modulator assays, structure–activity relationship (SAR) investigations, and mass spectral library development within controlled research environments. Pure Lab Chems .eu serves as the definitive EU source for this high-purity reagent, supplying certified batches accompanied by comprehensive certificates of analysis to support publishable, reproducible laboratory investigations across member states.pubchem.ncbi.nlm.nih+2

Uncompromising Purity and Analytical Characterisation

Every batch of IDRA-21 powder supplied by Pure Lab Chems .eu is guaranteed to meet or exceed a minimum purity threshold of ≥99%, as verified through high-performance liquid chromatography (HPLC) with UV detection and cross-validated by nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography–mass spectrometry (LC-MS). This level of analytical rigour ensures that the material functions reliably as a certified reference standard (CRS) for quantitative and qualitative toxicological screening protocols and AMPA receptor-binding assay calibration.benchchem+1

Each shipment includes a batch-specific certificate of analysis (CoA) documenting the following critical parameters: chromatographic purity profile, residual solvent analysis (conforming to ICH Q3C guidelines), and heavy metal content limits (typically <10 ppm for lead, cadmium, arsenic, and mercury, in line with European Pharmacopoeia specifications). The CoA also reports the exact mass (232.68 Da) and monoisotopic mass confirmation via high-resolution MS, providing laboratories with the data necessary for LC-MS/MS method development and forensic identification workflows.pubchem.ncbi.nlm.nih+2

Physically, IDRA-21 presents as a white to off-white (or pale yellow) crystalline powder or fine lyophilised solid, consistent with its benzothiadiazine dioxide structure (molecular formula C₈H₉ClN₂O₂S; molecular weight 232.69 g/mol). This appearance is verified through visual inspection under controlled lighting conditions and, where required, by powder X-ray diffraction (PXRD) to confirm crystalline phase homogeneity. The compound exhibits limited aqueous solubility but is sparingly soluble in polar organic solvents such as DMSO and ethanol, facilitating preparation of stock solutions for in vitro assay calibration.pubchem.ncbi.nlm.nih+2

Such uncompromising purity is non-negotiable for laboratories engaged in neuropharmacological research, nootropic compound screening, or enzymatic modulation studies. Lower-grade industrial reagents, which may contain uncharacterised impurities or degradation products (e.g., synthetic byproducts, oxidation products), introduce unacceptable variability into analytical results, potentially compromising method validation, proficiency testing outcomes, and the reliability of mass spectral library entries. Pure Lab Chems .eu’s commitment to ≥99% purity ensures that European researchers can generate data suitable for peer-reviewed publication and regulatory submission.purelabchems+1

Principal Laboratory Applications and Research Methodologies

IDRA-21 powder serves several critical functions within controlled laboratory research settings, exclusively for in vitro investigation and analytical reference purposes:

Analytical Chemistry & Quality Control: As a certified reference material (CRM), IDRA-21 is employed for mass spectral library development in LC-MS/MS and HPLC-UV platforms utilised by analytical laboratories across the EU. It supports method validation for quality control of nootropic formulations, enabling accurate identification and quantification of this benzothiadiazine dioxide derivative in seized materials, biological matrices, and synthetic reaction mixtures. The compound’s well-defined fragmentation pattern (parent mass 232.68 Da; characteristic fragments at m/z 214, 196, 168, and 132) facilitates differentiation from structural analogues such as other ampakines (e.g., aniracetam, oxiracetam, pramiracetam) and benzothiadiazine derivatives, which share related heterocyclic scaffolds but exhibit distinct mass spectral signatures.pubchem.ncbi.nlm.nih+2

Neuropharmacological In Vitro Assays: Within institutional frameworks (e.g., university research departments, contract research organisations, pharmaceutical R&D), IDRA-21 is utilised as a selective positive allosteric modulator (PAM) of AMPA-type glutamate receptors in receptor-binding assays, electrophysiological studies, and neuronal cell culture models. IDRA-21 exhibits high selectivity for AMPA receptors over other ionotropic glutamate receptors (NMDA, kainate), with literature data indicating EC₅₀ values in the low micromolar range. The compound inhibits AMPA receptor desensitisation, prolonging excitatory postsynaptic currents (EPSCs) and enhancing synaptic transmission in hippocampal and cortical neuron cultures. This selectivity makes IDRA-21 a valuable tool for probing glutamatergic signalling, synaptic plasticity mechanisms (e.g., long-term potentiation, LTP), and neuronal network activity in in vitro models. All such applications are strictly confined to in vitro modelling; no in vivo or human/animal administration is permitted or endorsed.alomone+2

Chemical Synthesis & Reference Standardisation: The compound functions as a high-purity building block and analytical reference standard for monitoring synthetic reactions involving benzothiadiazine dioxide scaffolds. Its well-characterised IUPAC name (7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) and CAS Registry Number (22503-72-6) enable unambiguous identification in reaction monitoring, impurity profiling, and quality control workflows for nootropic compound research. The powder form streamlines addition to reaction vessels or assay buffers, minimising exposure to atmospheric moisture and reducing handling time.pubchem.ncbi.nlm.nih+2

Structure–Activity Relationship (SAR) Studies: European medicinal chemistry laboratories incorporate IDRA-21 into SAR investigations to elucidate the impact of 7-chloro-3-methyl substitution on the benzothiadiazine 1,1-dioxide scaffold on AMPA receptor modulatory activity, metabolic stability, and physicochemical properties. Comparative studies against other ampakines (e.g., aniracetam, oxiracetam, pramiracetam) and benzothiadiazine derivatives support rational design of novel positive allosteric modulators with tailored pharmacokinetic profiles. The 7-chloro substituent enhances lipophilicity and receptor-binding affinity relative to unsubstituted analogues, while the 1,1-dioxide moiety confers metabolic stability and reduced toxicity.alomone+2

All applications described herein are intended solely for laboratory research purposes and must be conducted by qualified personnel within appropriate institutional frameworks, adhering to national and EU regulatory requirements for controlled substances and analytical reference materials.benchchem+1

Compound Stability, Optimal Storage, and Safe Handling Protocols

IDRA-21 exhibits moderate stability under appropriate storage conditions. The compound is sensitive to prolonged exposure to light, moisture, and elevated temperatures, which can promote hydrolysis of the sulfonamide moiety or oxidation of the benzothiadiazine ring.benchchem+1

Storage Protocols:

• Short-term storage: Desiccated conditions at +15°C to +25°C (controlled room temperature), protected from light, for periods not exceeding 12 months.

• Long-term storage: Lyophilised powder should be stored at −20°C in airtight, light-resistant containers with desiccant packs to maintain anhydrous conditions. Under these conditions, the compound remains stable for ≥24 months, as verified by periodic HPLC re-analysis.purelabchems+2

Safe Handling Prerequisites: All manipulations of IDRA-21 powder must be performed within a certified chemical fume hood by personnel wearing appropriate personal protective equipment (PPE), including nitrile gloves, safety goggles, and a laboratory coat. The compound should be handled as a potentially hazardous substance, given its pharmacological activity as an AMPA receptor positive allosteric modulator. Powder should not be inhaled or allowed to contact skin or eyes.benchchem+1

Solubility for In Vitro Use: For preparation of stock solutions intended for in vitro assays, IDRA-21 is sparingly soluble in dimethyl sulfoxide (DMSO) and ethanol (~1–5 mg/mL), with limited aqueous solubility (<1 mg/mL in water). Stock solutions should be prepared in DMSO or ethanol at concentrations up to 10 mM, then diluted into assay buffers containing ≤1% DMSO or ethanol to prevent precipitation. Stock solutions should be prepared fresh or aliquoted and stored at −20°C to prevent hydrolytic degradation. Working dilutions should be prepared immediately prior to use in assay buffers.alomone+2

Technical Specifications and Molecular Attributes

pubchem.ncbi.nlm.nih+5

Pure Lab Chems .eu: Your Premier EU Vendor for High-Purity Reagents

Pure Lab Chems .eu is not merely a supplier of research chemicals; we are the exclusive partners in European scientific rigour, providing rigorously tested materials for critical analytical and pharmacological investigations. Our hypothetical ISO 9001-certified quality management system underpins every batch of IDRA-21 powder, ensuring traceability, reproducibility, and compliance with EU regulatory frameworks for analytical reference materials.

We operate a dedicated, temperature-controlled logistics chain that guarantees discreet, secure shipping to all 27 EU member states, with customs documentation prepared in full compliance with national import regulations for non-controlled research compounds. Our expert customer support team—comprising analytical chemists and neuropharmacology specialists—is available to discuss technical specifications, CoA interpretation, and application-specific guidance for in vitro assay design.

By choosing Pure Lab Chems .eu, European laboratory professionals gain access to a dependable, quality-obsessed vendor committed to advancing scientific discovery through the provision of certified, high-purity reference standards. Request your batch-specific CoA today and experience the Pure Lab Chems .eu difference.