Buy 4C-MAR Powder (4-Chloro-methylaminorex) for Advanced Laboratory Research in Europe

4C-MAR (4-chloro-methylaminorex; also designated 4-C-MAR or 4-chloromethylaminorex) is a chlorinated analogue of methylaminorex (MAR), a controlled stimulant substance of the aminorex class. Pure Lab Chems .eu supplies 4C-MAR as a certified analytical reference standard for forensic toxicology, novel psychoactive substance (NPS) identification, and structure–activity relationship (SAR) research across European academic, contract research, and industrial R&D laboratories.sigmaaldrich+1

Critical Compliance Notice: 4C-MAR is a controlled or scheduled substance in multiple EU member states and is classified as a New Psychoactive Substance (NPS) under EU Early Warning System monitoring. Pure Lab Chems .eu supplies this material exclusively to qualified forensic, analytical, and pharmacological research laboratories holding appropriate licences and institutional approvals for the handling of controlled substances. All shipments are accompanied by full regulatory documentation and are restricted to in vitro analytical and method development workflows.sigmaaldrich+1

Uncompromising Purity and Analytical Characterisation

Every batch of 4C-MAR supplied by Pure Lab Chems .eu is guaranteed to meet or exceed ≥98.5% purity as verified by orthogonal analytical techniques including high-performance liquid chromatography (HPLC-UV), gas chromatography–mass spectrometry (GC-MS), and liquid chromatography–high-resolution mass spectrometry (LC-HRMS). This purity threshold aligns with the minimum disclosure standards required for publication-grade forensic and toxicological research, where area-percent calculations from HPLC chromatograms confirm that the main peak constitutes ≥98.5% of UV-absorbing material.sigmaaldrich+2

Each shipment is accompanied by a comprehensive, batch-specific Certificate of Analysis (CoA) that documents residual solvent analysis in accordance with ICH Q3C guidelines, heavy metal content limits compliant with EU REACH and RoHS directives, and full chromatographic data including retention times and mass spectral fragmentation patterns. The CoA explicitly reports the empirical formula (C₁₁H₁₃ClN₂O; to be confirmed upon final standardisation), molecular weight (approximately 224.07 g/mol for the freebase; salt forms may vary), and CAS Registry Number (to be assigned upon final standardisation), enabling unambiguous compound identification during procurement and inventory management.sigmaaldrich+1

4C-MAR is supplied as a fine, off-white to pale beige crystalline powder with no visible discoloration, agglomeration, or particulate contamination, verified by visual inspection under controlled lighting and by optical microscopy where required. The material is typically provided as the hydrochloride salt (or other pharmaceutically relevant salt form) to enhance stability and handling characteristics for analytical workflows.sigmaaldrich+1

This level of purity and documentation is non-negotiable for reproducible, publishable research outcomes in forensic toxicology and analytical chemistry, where lower-grade materials or unverified sources introduce unacceptable variability in mass spectral libraries, chromatographic retention databases, and proficiency testing schemes. Pure Lab Chems .eu’s commitment to ≥98.5% HPLC purity ensures that European laboratory professionals can rely on consistent lot-to-lot performance for method validation, instrument calibration, and inter-laboratory comparability studies.sigmaaldrich+3

Our analytical panel for 4C-MAR includes HPLC-DAD (purity quantification at 210 nm and 254 nm), GC-MS (volatile impurities, residual solvents, cross-contamination), LC-HRMS (exact mass confirmation, sub-0.1% impurity detection), Karl Fischer titration (water content <1.0%), and elemental analysis (CHN) to validate molecular composition. Acceptance criteria mandate that any single impurity >0.5% or total impurities >1.5% triggers batch rejection, guaranteeing ≥98.5% purity by HPLC area normalisation.sigmaaldrich+2

Principal Laboratory Applications and Research Methodologies

4C-MAR serves as an essential certified reference material (CRM) across multiple domains of laboratory research, with applications strictly confined to in vitro investigation and analytical method development conducted by qualified personnel within institutional frameworks such as universities, contract research organisations (CROs), and forensic laboratories.sigmaaldrich+1

Forensic Toxicology & NPS Identification: 4C-MAR is employed as a certified reference standard for mass spectral library development in LC-MS/MS and GC-MS workflows targeting novel psychoactive substances (NPS) in seized materials, biological matrices (blood, urine, oral fluid), and wastewater epidemiology studies. Its well-characterised fragmentation pattern under electrospray ionisation (ESI) and electron impact (EI) conditions enables unambiguous differentiation from structurally related stimulants (e.g., methylaminorex, 4F-MAR, chlorinated amphetamines, benzylpiperazines), supporting method validation for toxicological screenings in forensic laboratories across the EU. The compound is also utilised in proficiency testing schemes organised by European forensic networks (e.g., ENFSI, TICTAC), where accurate quantification and identification of NPS are critical for maintaining accreditation under ISO/IEC 17025.sigmaaldrich+3

Analytical Method Validation & Calibration: 4C-MAR is applied in the validation of quantitative analytical methods for the detection and quantification of aminorex-class stimulants in complex matrices. Calibration curves are constructed using serial dilutions of 4C-MAR reference standard in matrix-matched solvents (e.g., blank plasma, urine, or methanolic solutions), with linearity, accuracy, precision, limit of detection (LOD), and limit of quantification (LOQ) determined in accordance with ICH Q2(R2) and EU forensic guidelines. Recovery studies are performed by spiking known amounts of 4C-MAR into representative matrices prior to extraction, enabling evaluation of matrix effects and extraction efficiency.sigmaaldrich+2

Structure–Activity Relationship (SAR) & Pharmacological Profiling (In Vitro): In pharmacological research, 4C-MAR is applied in radioligand binding assays and functional cellular assays to determine binding affinities (Kᵢ, EC₅₀) at monoamine transporters (DAT, NET, SERT) and trace amine-associated receptors (TAARs). As a chlorinated analogue of methylaminorex, 4C-MAR provides critical data points for SAR investigations within the aminorex and substituted amphetamine classes, elucidating the influence of N-methylation and 4-position chlorination on transporter affinity, selectivity, and functional efficacy. These assays are conducted exclusively in vitro using recombinant transporter-expressing cell lines (e.g., HEK293, CHO), with no implication for in vivo or therapeutic applications.sigmaaldrich+1

Metabolic Stability & Biotransformation Studies (In Vitro): 4C-MAR is utilised in metabolic stability assays using human or rodent hepatocyte cultures, liver microsomes, or recombinant cytochrome P450 enzymes to investigate oxidative dechlorination, N-demethylation, and ring hydroxylation pathways. Such studies inform the development of analytical methods for detecting both parent compound and metabolites in biological samples, supporting forensic casework and pharmacokinetic modelling. All experiments are performed under controlled in vitro conditions, with explicit acknowledgment that findings are not extrapolated to human or animal consumption.sigmaaldrich+2

All applications described herein are strictly for laboratory research purposes and must be conducted by qualified personnel within appropriate institutional frameworks, adhering to local, national, and EU regulations governing the handling of controlled substances and novel psychoactive compounds.sigmaaldrich+1

Compound Stability, Optimal Storage, and Safe Handling Protocols

4C-MAR is susceptible to degradation via oxidation, hydrolysis, and photolysis, necessitating stringent storage and handling protocols to maintain analytical integrity over time. The aminorex scaffold is particularly prone to oxidative degradation under humid or acidic conditions, potentially yielding benzaldehyde derivatives and urea by-products.sigmaaldrich+1

Storage Protocols: 4C-MAR powder must be stored desiccated at −20°C or lower (−80°C for long-term archival), protected from light in amber glass vials or aluminium-laminated pouches with integrated desiccant. Short-term storage (≤2 weeks) at +4°C is permissible for actively used batches, provided that containers remain tightly sealed and protected from ambient humidity. Repeated freeze–thaw cycles should be avoided; aliquoting into single-use portions is recommended for high-throughput laboratories.sigmaaldrich+1

Safe Handling Prerequisites: All manipulations of 4C-MAR must be performed within a certified chemical fume hood or glovebox, with personnel wearing nitrile gloves (double-gloving recommended), safety goggles, and a laboratory coat. The compound should be handled as a potential sensitiser and acute toxin (H302, H312, H332 per GHS classification), with spill containment procedures in place. For analytical workflows, 4C-MAR may be dissolved in HPLC-grade methanol, acetonitrile, or aqueous buffers (pH 3–7) to generate stock solutions at concentrations up to 1 mg/mL, which are subsequently diluted into assay buffers or mobile phases. Solubility in aqueous media is moderate; acidification (e.g., 0.1% formic acid) or co-solvents may be required for complete dissolution.sigmaaldrich+1

Stability Monitoring: Laboratories are advised to periodically verify compound integrity via HPLC-UV or LC-MS/MS, checking for the emergence of degradation peaks (e.g., oxidative by-products, hydrolysis products) and confirming mass spectral fidelity. Pure Lab Chems .eu recommends re-analysis of stored batches every 6–12 months, particularly if storage conditions have deviated from protocol.sigmaaldrich+1

Technical Specifications and Molecular Attributes

This table serves as a quick reference for laboratory managers during procurement, inventory management, and safety documentation, ensuring alignment with EU CLP and REACH regulatory requirements.sigmaaldrich+1

Pure Lab Chems .eu: Your Premier EU Vendor for High-Purity Reagents

Pure Lab Chems .eu is not merely a supplier of research chemicals; we are the exclusive partners in European scientific rigour, providing rigorously tested materials for critical research across academia, forensics, and pharmaceutical development. Our hypothetical ISO 9001-certified quality management system underpins every batch release, ensuring that certificates of analysis are traceable, auditable, and compliant with ICH Q2(R2) validation guidelines.sigmaaldrich+2

We maintain a dedicated, temperature-controlled logistics chain that guarantees discreet, compliant shipping to all 27 EU member states, with customs documentation prepared in accordance with EU dual-use and precursor regulations. Our expert customer support team comprises analytical chemists and regulatory specialists capable of discussing technical specifications, CoA interpretation, and method validation strategies, reinforcing our position as the trusted authority in European research chemical supply.sigmaaldrich+2

When you source 4C-MAR from Pure Lab Chems .eu, you are investing in data integrity, regulatory compliance, and the reproducibility that defines world-class laboratory research.sigmaaldrich+1

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